在自闭症谱系障碍中,亲子多个微生物和代谢特征的部位
Lingping Zhu1,2, Haiyan Zhang1, Meiling Tang3
1The Affiliated Nanhua Hospital, Department of General Practice, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Frontiers in microbiology
|February 9, 2026
概括
自闭症家族表现出改变的口腔和肠道微生物,具有明显的代谢变化,可能与家族传播和自闭症发展有关. 这项研究突出了自闭症谱系障碍 (ASD) 病理生理学的口腔肠轴.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 自闭症谱系障碍 (ASD) 研究研究
背景情况:
- 口腔肠轴在健康和疾病中起着至关重要的作用.
- 肠道微生物组的变化越来越多地与神经发育障碍有关,如ASD.
- 了解微生物群的家族传播模式是调查ASD病原学的关键.
研究的目的:
- 研究自闭症谱系障碍 (ASD) 家庭内口腔肠道微生物群的水平传播.
- 探索这些微生物相互作用对ASD病原学的潜在影响.
- 在家庭背景下识别与ASD相关的特定微生物和代谢特征.
主要方法:
- 配对队列设计比较ASD和非ASD家庭队列.
- 口腔和便样本的综合微生物组和代谢分析.
- 统计分析包括微生物多样性,组成和代谢途径概况.
主要成果:
- 自闭症家族表现出增加的口腔微生物多样性和改变的肠道微生物群组成 (较低的Firmicutes/Bacteroidetes比率).
- 观察到显著的代谢干扰,包括L-rhamnose降解和谷氨代谢受损.
- 确定了协调的口肠轴变化和特定的微生物-代谢物相关性,其中甘氨基具有高预测价值.
结论:
- 自闭症家族表现出特有的口腔肠道微生物群相互作用和代谢异常.
- 这些发现表明潜在的家族微生物传播模式有助于ASD病理生理学.
- 口腔肠轴代表了ASD的潜在治疗目标.
更多相关视频
08:30Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
Published on: September 6, 2024
2.6K
07:56Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
Published on: September 19, 2019
10.8K
相关概念视频
01:19Autism Spectrum Disorder
1.2K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.2K
02:37The Electromagnetic Spectrum
65.5K
The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
65.5K
00:55Parental Care
12.8K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
12.8K
01:27Parenting Styles
697
Diana Baumrind's four parenting styles — authoritarian, authoritative, neglectful, and permissive — each influence children's socio-emotional development differently.
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative...
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative...
697
01:49Conserved Binding Sites
5.2K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.2K
01:19IR Spectrum
2.3K
When infrared (IR) radiation passes through a molecule, the bonds stretch or bend by absorbing the radiation. This absorption creates the molecule's absorption spectrum, which is the plot of its percentage transmittance versus wavenumber.
Transmittance is defined as the ratio of the radiant power passing through a sample to that from the radiation's source. Multiplying the transmittance by 100 gives the percent transmittance (%T), which varies between 100% (no absorption) and 0%...
Transmittance is defined as the ratio of the radiant power passing through a sample to that from the radiation's source. Multiplying the transmittance by 100 gives the percent transmittance (%T), which varies between 100% (no absorption) and 0%...
2.3K