通过基于结直肠癌的化疗,在手术后为局部复发的状神经内分泌癌实现了病理完整的反应:一个病例报告
Kana Kajisako1, Taro Tanabe1, Naho Nishibayashi1
1Digestive Diseases Center, Showa Medical University Koto Toyosu Hospital, Tokyo, Japan.
Surgical case reports
|February 9, 2026
概括
结肠神经内分泌癌 (NEC) 很少见,难以诊断. 一名患有复发性乳腺癌NEC的患者使用结直肠癌化疗方案实现了完全反应,这表明这种方法可能是有效的.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 结肠的原发性神经内分泌癌 (NEC) 是一种罕见的恶性瘤 (0.2%的结肠直肠癌),预后不佳.
- 早期诊断是具有挑战性的,因为活检可能被误解为腺癌.
- 对结直肠NEC的标准化疗方案尚未建立,尽管以为基础的疗法是常见的.
研究的目的:
- 报告一个局部复发的Cecal NEC病例.
- 评估基于结直肠癌的化疗方案在实现病理完整反应方面的疗效.
主要方法:
- 一名52岁的男性患有性NEC (IIIB阶段) 接受了手术和初始基于的化疗.
- 通过升高的癌胚抗原 (CEA) 和成像检测发现了复发.
- 化学疗法被切换到FOLFOXIRI加贝瓦西祖马布 (结肠直肠癌治疗方案).
主要成果:
- 患者在7个FOLFOXIRI加贝瓦西祖马布治疗周期后实现了放射性回归和CEA水平的正常化.
- 复发性病变的切除证实了病理完整的反应,没有剩余的瘤细胞.
结论:
- 这是首次报告的乳头NEC病例,通过基于结直肠癌的治疗方案实现了病态完全回归.
- 结肠直肠NEC可能对基于的和基于结肠直肠癌的化疗都有反应.
- CEA水平可以作为指导结直肠NEC化学疗法选择的生物标志物.
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