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Updated: Feb 10, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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基于佐和西的尿素衍生物的结构导向设计,通过同时抑制VEGFR-2,EGFR和c-Met来限制瘤信号传递

Sadia Shaheen1, Arshma Siddique1, Ali Iftikhar2

  • 1Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.

ACS omega
|February 9, 2026
PubMed
概括

新的丁和丁尿素衍生物显示了像VEGFR-2,EGFR和c-MET.等受体氨酸激酶 (RTK) 的多目标抑制. 这些化合物表现出强大的抗增殖和抗血管效应,具有低毒性,为癌症治疗提供了希望.

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