基于光子晶体微球的SERS生物传感器用于超敏感检测料中的阿弗拉托克辛B1
Yuxuan Chen1, Ruipeng Chen1, Hui Wang1
1State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China.
ACS omega
|February 9, 2026
概括
一种使用光子晶体微球 (PCM) 的新型表面增强拉曼散射 (SERS) 传感器,可实现对阿弗拉托克辛B1 (AFB1) 的超敏感检测. 这种先进的传感器为料安全监控提供了广泛的检测范围和高灵敏度.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 非洲毒素B1 (AFB1) 是一种致癌性菌毒素,对料和人类健康构成风险,需要敏感的检测方法.
- 现有的方法在微量检测和复杂的样本矩阵方面存在困难.
研究的目的:
- 开发一个表面增强的拉曼散射 (SERS) 传感器,用于AFB1.1的广泛和超敏感的定量检测.
- 为了提高检测性能,利用光子晶体微球 (PCM) 和金银纳米星纳米标签.
主要方法:
- 制造SERS纳米标签使用金银核心外纳米星与拉曼记者分子.
- 纳米标签与光子晶体微球 (PCM) 的集成,以创建SERS传感器.
- 使用SERS对AFB1进行定量检测,分析检测极限 (LOD) 和线性动态范围 (LDR).
主要成果:
- 开发的传感器实现了0.988 pg/mL的超低LOD和从1 pg/mL到100 ng/mL的广泛LDR.
- 传感器表现出极好的特异性,可重复性和稳定性,在14天后保持了89.2%的性能.
- 实际应用表明与商业酶链免疫吸收试验 (ELISA) 套件的一致性很好.
结论:
- 基于PCM的SERS传感器提供了一个高度敏感和可靠的平台,用于跟踪AFB1检测.
- 这种方法在料安全监测方面具有重大潜力,提供了一个全新的综合分析平台.
- 传感器的性能表明,它是快速准确的真菌毒素分析的有希望的替代方案.
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