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化功能化纤维素纳米纤维水凝,用于通过动态内胺结合通过pH敏感药物输送

Hiroya Tsubota¹, Jeongjin Park², Hyoungwook Kang³

¹Chemical Engineering Program, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527 Japan.

|February 9, 2026

概括

这项研究引入了一种基于纤维素的新型水凝,该水凝可以释放药物,以应对与疾病相关的pH值变化. 智能水凝提供可调节的药物输送和增强的稳定性,显示了针对性癌症治疗的希望.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
药物输送系统药物输送系统

背景情况:

智能水凝为向药物输送提供了潜在的潜力.
控制水凝网络密度对于可调节的药物释放至关重要.
酸催化反应为响应性材料设计提供了一种机制.

研究的目的:

开发一种基于纤维素的水凝系统,能够响应与疾病相关的pH.
调查酸催化胺基键形成在控制水凝特性和药物释放中的作用.
评估开发的水凝系统的生物相容性和治疗疗效.

主要方法:

制造化物功能化的TEMPO氧化纤维素纳米纤维 (A-TOCNF) 和甘基托 (GC) 水凝.
使用酸催化胺基键形成用于交叉连接和网络密度控制.
在不同的pH条件下评估药物释放动力学 (DOX,α-MS).
描述水凝结构 (SEM) 和机械性能 (AFM).
评估细胞活力和抗癌疗效 (WST-8试验).

主要成果:

水凝表现出pH依赖的药物释放,在酸性条件下由于胺基键水解而加速释放.
一个酸催化剂增强了交叉链接,创造了一个更密集的网络并抑制了药物释放.
SEM和AFM证实了酸催化水凝的结构紧性和机械稳定性增加.
实验室研究验证了水凝的生物相容性和DOX载荷配方的抗癌疗效.

结论:

开发的基于纤维素的水凝系统展示了可调节,pH响应的药物输送能力.
酸催化胺基键形成是控制水凝网络密度和药物释放动力学的有效策略.
这种可生物降解的平台显示出对特定地点和持续药物输送的巨大潜力,特别是对于含氨酸的治疗药物.

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