使用基于凝的微封装增强巴西红色的物理化学特性
Jesudunni Aanuolu Akinola1, Wedja Timóteo Vieira1, Wanderley Pereira Oliveira1
1School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, Brazil.
ACS omega
|February 9, 2026
概括
使用喷雾干燥将红色提取物 (RPE) 与Gelucire 50/13进行封装,可显著提高其溶解性和稳定性. 这种方法改善了RPE的物理化学特性,使其更加生物可用.
科学领域:
- 自然产品 化学 化学
- 制药技术 制药技术 制药技术
- 食品科学 食品科学 食品科学
背景情况:
- 红色提取物 (RPE) 具有宝贵的药理性质,但由于其疏水性质,其口服生物利用性较差.
- 封装技术,如喷雾干燥,对于提高疏水性天然产品的可溶性和稳定性至关重要.
- 凝露50/13是一种表面活性剂,因其提高药物溶解性和生物可用性的潜力而得到认可.
研究的目的:
- 评估Gelucire 50/13对喷雾干燥红蜂提取物 (RPE) 的物理化学特性的影响.
- 评估不同载体 (阿拉伯,OSA改性粉,马尔托德) 对用Gelucire封装RPE的影响.
- 为了比较用Gelucire封装的RPE与普通RPE配方的特性.
主要方法:
- 对于固体含量和总黄酸含量 (TFC) 的RPE的表征.
- 用Gelucire 50/13封装RPE,并使用阿拉伯口香糖,OSA改性粉和马尔托德克斯特林进行喷雾干燥.
- 配方的物理化学表征 (水活性,水分含量,可溶性) 和HPLC分析化学完整性.
主要成果:
- RPE的TFC为13.11毫克克尔丁等价物.
- 与普通的RPE配方相比,RPE-Gelucire配方表现出更好的喷雾干燥产量和增强的物理化学特性.
- 通过HPLC分析证实,在封装后,RPE的化学特征保持不变.
结论:
- 结合喷雾干燥和合适的载体,Gelucire 50/13有效地提高了红色提取物的可溶性和稳定性.
- 这种封装策略改善了RPE的物理化学特性,为更好的口服输送铺平了道路.
- 这些发现支持使用基于Gelucire的封装来优化水性天然提取物如巴西红色的输送.
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