免疫炎症指数与痛风发作风险之间的关联:系统性审查和元分析
Zhiwei Guan1, Minjun Zhang1, Ye Yuan2
1Geriatrics Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Therapeutic advances in musculoskeletal disease
|February 9, 2026
概括
中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 能够有效预测急性痛风发作. 建议进行进一步的大规模前性研究,以证实这些免疫-炎症指数的发现.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 生物统计学 生物统计学
背景情况:
- 痛风发作与免疫和炎症标志物有关.
- 使用免疫-炎症指数预测痛风发作的证据有限.
研究的目的:
- 为了评估急性痛风发作免疫炎症指数的预测值.
主要方法:
- 8篇文章的系统审查和元分析,共有2655名参与者.
- 搜索了PubMed,科学网,Embase,Cochrane,CNKI和万芳. 这是一个很好的例子.
- 使用标准化平均差异 (SMD) 和随机效应模型分析了中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR).
主要成果:
- 无论是NLR (SMD:0.75;95%CI:0.48-1.03) 和PLR (SMD:0.52;95%CI:0.24-0.79) 都显著预测了急性痛风发作.
- 敏感性分析证实了NLR和PLR在预测中的稳定性.
- 亚组分析表明NLR和PLR是所有亚组的显著预测因素,年龄和样本大小可能会影响PLR异质性.
结论:
- 对于急性痛风发作,NLR和PLR显示出强大的预测性能.
- 该研究强调需要大规模的前性研究来验证这些发现,因为现有的研究有限和异质性.
更多相关视频
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
10.6K
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
1.2K
相关概念视频
Inflammation
62.3K
Overview
62.3K
What is the Immune System?
131.2K
Overview
131.2K
Acid Attack on Concrete
780
When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
The rate at which hydrogen...
780
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.6K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Sulfate Attack on Concrete
771
Sulfate attack on concrete is a deterioration process characterized by a whitish discoloration beginning at the edges and corners, accompanied by cracking and spalling. This phenomenon occurs when sulfates react with the components of hardened concrete, forming compounds like calcium sulfate and calcium sulfoaluminate which occupy more space than the substances they replace, causing the concrete to expand and disrupt.
Sulfates from sources like soil, groundwater, or industrial effluents...
Sulfates from sources like soil, groundwater, or industrial effluents...
771
