在患有双相情感障碍的患者中,认知功能的性别差异
Zhonggang Wang1, Gong Zhang1, Haining Song1,2
1Department of Psychiatry, Shandong Daizhuang Hospital, Jining, Shandong, China.
Frontiers in public health
|February 9, 2026
概括
性行为显著影响双相情感障碍 (BD) 的认知功能. 男性BD患者表现出更多的注意力和认知转移缺陷,而女性则经历了更大的记忆障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 双极性障碍 (BD) 是一种严重的精神疾病,具有高复发率和认知缺陷.
- 性差异影响BD的临床特征,但它们对认知的影响尚不清楚.
- 了解BD中的性别特异性认知概况对于有针对性的干预至关重要.
研究的目的:
- 调查性在塑造认知特征中的角色,在一大批首次诊断为双相情感障碍患者的样本中.
- 为了比较男性和女性BD患者和健康对照者的认知表现.
主要方法:
- 研究了一组243人 (168人首次诊断为BD,75人健康对照) 的队列.
- 用连续性能测试 (CPT),数字跨度测试 (DST) 和威斯康星卡排序测试 (WCST) 评估认知功能.
- 在不同组 (BD与对照组) 和性别 (男性与女性) 之间进行了绩效比较.
主要成果:
- 在CPT,DST和WCST上观察到显著的群体效应.
- 在WCST (p<0.05) 上发现了总被管理 (TA) 和非持续性错误 (NPE) 的显著群体和性别影响.
- 男性BD患者的TA和NPE得分高于女性BD患者. 住院的频率与注意力得分有负相关性.
结论:
- 无论是男性还是女性,BD患者都表现出认知障碍.
- 性在首次诊断BD患者的认知功能中起着重要作用.
- 男性患者可能在注意力和认知转移方面有更大的缺陷,而女性可能更容易出现记忆障碍.
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