中国南部高尿血和结石之间的关联:一个多中心的横截面研究
Yuwen Zhong1, Rongxin He2, Ganglin Kang1
1Department of Pathology, Luzhou Maternal and Child Health Hospital (Luzhou Second People's Hospital), Luzhou, China.
Frontiers in endocrinology
|February 9, 2026
概括
高尿路血症增加了结石的风险. 年龄,BMI和异常的尿检是关键的危险因素,而饮用水是保护性的,特别是对于44岁以下的人来说.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 流行病学 流行病学
背景情况:
- 高尿路血是结石的重要危险因素.
- 在一般人群中对高尿血和结石患病率的研究是有限的.
- 中国南部的结石发病率很高,需要对风险进行鉴定.
研究的目的:
- 调查中国南部高尿血和结石患病率之间的相关性.
- 在高尿血症患者中确定结石的独立风险因素和保护因素.
- 分析年龄,BMI,血清尿酸和石风险之间的剂量反应关系.
主要方法:
- 多中心横截面研究 (2022-2024) 使用来自2739个人的健康检查数据.
- 后勤回归以确定高尿血症中结石的独立风险因素.
- 对年龄,BMI和血清尿酸关系的限制立方线 (RCS) 和值效应分析.
主要成果:
- 结石的患病率在高尿血症患者中为25.48% (24.21%的男性,1.28%的女性).
- 独立的危险因素:年龄,BMI,血清尿酸,性别,尿液白细胞/红细胞异常.
- 保护因素:摄入水. 年龄与结石风险之间的非线性关系 (P < 0.001).
结论:
- 年龄,BMI,血清尿酸,性别和尿液异常是高尿血症患者结石的独立危险因素.
- 充足的饮用水是预防结石的保护因素.
- 结石的风险随着年龄的增长而非线性地增加,在44岁以下的人群中出现显著增加.
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