慢性鼻炎的神经精神病学后续:使用多机构电子健康记录网络进行回顾性队列研究
Ioannis Zerefos1, Zachary Li2, Katherine M Napalinga1
1Psychiatry, Reading Hospital, Tower Health, West Reading, USA.
Cureus
|February 9, 2026
概括
与没有鼻息肉 (CRSsNP) 的慢性鼻炎患者相比,患有鼻息肉 (CRSwNP) 的慢性鼻炎患者的自杀念头和精神疾病风险较低. 建议对免疫调节进行进一步的研究.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 慢性鼻炎 (CRS) 是一种普遍的炎症状况,影响生活质量.
- 在CRS中,系统性炎症可能与神经精神疾病,如抑郁症和自杀倾向有关.
- CRS的表型变化,特别是带有鼻息肉的CRS (CRSwNP) 和没有鼻息肉的CRS (CRSsNP),可能会影响精神病学的结果.
研究的目的:
- 调查CRSwNP和CRSsNP表型与自杀倾向之间的差异关联.
- 评估CRSwNP/CRSsNP与各种精神疾病发生率之间的关系.
主要方法:
- 使用ICD-10代码 (2010-2023) 诊断出CRSwNP或CRSsNP的成年人的回顾性队列分析.
- 倾向得分匹配创建了两个匹配的队列 (每一个n=130,769),用于控制混因子.
- 主要结局:自杀的想法和尝试. 二次结果:抑郁,焦虑,双相情感障碍,精神分裂症,精神分裂情感障碍,精神病.
主要成果:
- 与CRSsNP患者 (p<0.001) 相比,CRSwNP患者的自杀念头 (RR 0.66) 和自杀企图 (RR 0.63) 的风险明显较低.
- CRSwNP还与抑郁症 (RR 0.80),泛性焦虑症 (RR 0.75),双相情感障碍 (RR 0.72),精神分裂症 (RR 0.63),精神分裂情绪障碍 (RR 0.63),精神病 (RR 0.64) 的风险降低有关.
- 虽然在统计学上显著,但对二次结果的绝对风险差异很小.
结论:
- 与CRSsNP相比,CRSwNP与几种精神疾病的风险明显较低.
- 潜在的机制包括不同的炎症途径或不同的治疗效果.
- 研究结果提倡将精神病学查纳入CRS管理,并探索免疫调节以减少神经精神病风险.
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