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Updated: Feb 10, 2026

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临床干细胞疗法在口腔和面骨的再生:一个系统的审查和元分析
Parham Hazrati1, Abdulmohsen Alanazi1, Abdusalam E Alrmali1,2
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, United States.
Frontiers in bioengineering and biotechnology
|February 9, 2026
概括
干细胞治疗显示了大面骨再生的潜力,改善了组织学骨质量和体积. 然而,需要进一步的标准化试验来确认临床益处超过传统方法.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 口腔和牙面部外科手术
背景情况:
- 大和面部骨的再生面临着与传统技术的挑战.
- 干细胞疗法通过分化和信号传递提供了潜在的潜力.
- 干细胞治疗对骨再生的临床疗效仍在争论中.
研究的目的:
- 系统地审查和元分析干细胞治疗在口腔和面骨再生中的安全性和有效性.
- 评估各种手术指标和干细胞类型的结果.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science进行了全面的搜索 (2024年7月).
- 包括59项前性研究 (RCT,受控临床试验,单臂研究).
- 使用Cochrane RoB 2和ROBINS-I工具进行偏差风险评估.
主要成果:
- 干细胞治疗显示出临床和组织学上的好处,特别是在再生骨质和成熟度方面.
- 分析结果显示,组织学骨质量得到改善 (p=0.0446),骨体积显著增加 (p=0.0218).
- 在线性骨尺寸或临床附着水平增加方面没有观察到显著的改善.
结论:
- 干细胞疗法显示了对大面骨再生的承诺,提高骨质量和体积.
- 研究之间的异质性需要标准化的临床试验来获得明确的证据.
- 需要进一步的研究,以建立一致的报告,并确认治疗效益.
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