前PALM:一种负压通风系统,用于在活体肺部评估空气泄漏
Mark Vartazarmian1,2, Alexandre Abid2, Rodin Chermat2
1Department of Mechanical Engineering, Institute of Biomedical Engineering, Polytechnique Montréal, Montreal, QC, Canada.
Frontiers in bioengineering and biotechnology
|February 9, 2026
概括
一个新的ex vivo肺模型,Ex-PALM,准确地评估肺部手术后的长期空气泄漏 (PAL). 该系统有助于了解PAL的原因,并制定新的缓解策略.
科学领域:
- 肺部医学 肺部医学
- 生物医学工程 生物医学工程
- 胸部外科手术 胸部外科手术
背景情况:
- 长时间的空气泄漏 (PAL) 是肺部手术后术后并发症的主要原因.
- 目前用于评估PAL原因的方法在临床上不是有效的或系统的.
- 需要先进的临床前模型来研究PAL.
研究的目的:
- 为PAL评估而设计的肺部负压通风的新型ex vivo系统的引入和验证.
- 评估系统动态控制通风和量化空气泄漏的能力.
- 将系统的性能与标准商业设备进行比较,并评估其研究PAL机制的潜力.
主要方法:
- 开发了一种直观的,生理学上具有代表性的,具有PAL特定特征的肺部负压出体通风系统.
- 使用可控制缺陷区域的肺模拟模型评估系统的可重现性和功能.
- 用ex vivo肺样本验证了该系统,并将泄漏量化与商业数字胸腔排水系统 (Thopaz+) 相比较.
主要成果:
- 该系统证明了动态通风控制 (PCV/VCV) 在中度和严重的空气泄漏中具有较低的标准偏差.
- 泄漏量测量与Thopaz+可比,在较低的泄漏范围 (<400毫升/分钟) 没有显著差异.
- 该系统准确地复制了咳,并允许提取具有高合适度 (R2 > 0.95) 的生物力学参数.
结论:
- 活体肺空气泄漏模型 (Ex-PALM) 为PAL测试提供了一个临床前平台,具有很高的转化潜力.
- 该系统可用于研究 PAL.的基础上的生物力学机制.
- 前PALM促进了内部策略的发展,以减轻长时间的空气泄漏.
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