在口腔和唇部SCC中Gal-3表达:通过免疫组织化学进行细胞病理相关性
Negin Alahkhani1, Farnaz Mohajertehran2, Armaghan Salehi3
1Oral and Dental Diseases Research Center, Kerman University of Medical Science, Kerman, Iran.
Reports of biochemistry & molecular biology
|February 9, 2026
概括
盖列-3 (Gal-3) 在口腔和唇状细胞癌 (SCCs) 中表达的高于正常组织. 这种增加的Gal-3表达,特别是核染色,与口腔SCC中的侵略性特征相关,表明其作为生物标记物的潜力.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 分子生物学分子生物学
背景情况:
- 口腔和唇状细胞癌 (OSCC) 是具有较差预后的侵袭性头癌.
- 加勒-3 (Gal-3) 是一种涉及癌细胞增殖,亡和转移的蛋白质.
研究的目的:
- 评估和比较唇部和口腔SCCs中的Gal-3表达.
- 研究Gal-3在唇部和口腔SCCs的生物行为中的作用.
主要方法:
- 在OSCC,唇部SCC和对照组织中对Gal-3表达的免疫组织化学分析.
- 评估临床病理参数,包括侵袭前部,侵袭深度以及肌肉,神经和血管侵袭.
- 组之间的Gal-3染色百分比,强度和细胞位置的比较.
主要成果:
- 在SCC中,Gal-3染色明显高于对照组 (P<0.001).
- 与唇部SCC相比,口腔SCC显示Gal-3的染色强度和核染色更高 (P<0.001,P<0.010).
- 核Gal-3与OSCC的肌肉入侵相关 (P=0.030),高侵入性前部状态与唇部SCC中的Gal-3相关 (P=0.010).
- 在有血管入侵的OSCC中观察到更高的染色强度 (P=0.016).
结论:
- 在OSCC中高高的Gal-3表达和核定位可能导致其侵略性.
- 由于其在癌症组织中的表达增加,Gal-3显示出作为诊断和预后生物标志物的潜力.
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