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Updated: Feb 10, 2026

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在多发性硬化症无症状阶段的视神经和敏感性成像:影响和预测价值
Jean-Christophe Lafontaine1,2, Cécile Bordier3, Julien Labreuche4
1Centre de Ressources et Compétences Sclérose En Plaques (CRCSEP) de Lille, Department of Neurology, CHU Lille, Lille F-59000, France.
Brain communications
|February 9, 2026
概括
无症状的视神经病变在早期多发性硬化症 (放射学隔离综合征) 中很常见,并且与视网膜稀薄有关. 这些病变,以及偏磁边缘病变,可能表明疾病进展的风险更高.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 眼科医生 眼科 眼科
背景情况:
- 视神经受损是多发性硬化症 (MS) 的关键诊断标准.
- 放射性隔离综合征 (RIS) 是MS最早的阶段,通常无症状.
- 之前的研究发现RIS的视网膜变化很小,但无症状的视神经病变仍未评估.
研究的目的:
- 为了确定RIS患者视神经病变的频率.
- 评估这些病变对视网膜厚度的影响.
- 探索视神经病变和MRI发现与疾病进展的关联.
主要方法:
- 32名未经治疗的RIS患者的回顾性队列研究 (2020年8月至2024年12月).
- 每年脑部MRI和同一天的光学连贯性断层扫描 (OCT) 来测量视网膜厚度.
- 定期进行临床检查,以监测疾病转化.
主要成果:
- 在32名患者中,有9名患者 (28.1%) 在MRI上出现视神经病变.
- 眼睛的视神经病变显示显著更薄的周状视网膜神经纤维层 (p=0.003).
- 与非转换者 (25.9%) 相比,转换为临床MS的患者更有可能患有视神经病变 (60%) 和偏磁边缘病变 (60%).
结论:
- 沉默的视觉神经病变在RIS中很常见,并导致亚临床视网膜神经轴突损失.
- 视神经损伤或偏磁边缘损伤的存在可能预测RIS患者临床转换的风险更高.
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