儿童的认知功能和心血管疾病风险因素,直到60年后:两项出生队列研究的数据汇总
medRxiv : the preprint server for health sciences
|February 9, 2026
概括
儿童时代较高的认知功能 (IQ) 与成人时心血管疾病 (CVD) 风险因素较少有关. 这种关联表明潜在的途径和遵守健康建议的问题,影响长期的心血管健康.
科学领域:
- 流行病学 流行病学
- 认知科学 认知科学
- 心血管健康 心血管健康
背景情况:
- 儿童的认知功能 (IQ) 与成人心血管疾病 (CVD) 风险相反相关.
- 将早期认知与晚期心血管疾病风险联系在一起的具体机制尚不清楚.
- 这项研究探讨了儿童认知能力与成年心血管疾病风险因素的关系.
研究的目的:
- 检查儿童认知能力与中老年多重心血管疾病风险因素之间的关联.
- 确定可能调解认知和心血管疾病之间的联系的生物,心理和行为风险因素.
- 探索可能的机械路径,将早期认知功能与晚期心血管健康结果联系起来.
主要方法:
- 利用了来自英国两项大型前性出生队列研究 (1958年和1970年) 的数据.
- 认知功能通过儿童 (大约10岁) 的书面测试来评估.
- 在中年/老年人群中测量了16种生物,心理和行为风险因素;使用回归分析分析了相关性.
主要成果:
- 儿童时代较高的认知能力与成年时更有利的心理社会,行为和生物心血管疾病风险因素水平有关.
- 关联的强度从生物学因素增加到行为因素,然后是心理社会因素.
- 观察到与包括体重指数,甘油三,吸烟,抑郁症状和职业声望在内的因素有显著的相关性.
结论:
- 儿童的认知功能通过各种机制性途径与广泛的成人心血管疾病风险因素有关.
- 儿童的认知能力下降可能与风险因素的负担更大,以及潜在的预防性健康建议的遵守率更低有关.
- 这些发现强调了在理解和预防心血管疾病时考虑认知功能的重要性.
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