与社区肥胖相关的肝功能测试的时间变化:Colaus和PsyCoLaus研究
Manon Scyboz1, Noushin Sadat Ahanchi2, Montserrat Fraga3
1Faculty of Sciences and Medicine, University of Fribourg, Fribourg, Switzerland.
EJIFCC
|February 9, 2026
概括
肝功能测试 (LFTs) 随着年龄和性别而变化. 这些变化与体脂肪测量密切相关,这凸显了在解释LFT结果时考虑脂肪的重要性.
科学领域:
- 老年学是一门学科.
- 临床生物化学 临床生物化学
- 流行病学 流行病学
背景情况:
- 肝功能测试 (LFTs) 受各种因素的影响,但它们随着时间的推移而发生的变化,特别是关于衰老和肥胖的变化,尚不清楚.
- 不同年龄组和性别LFT的时间趋势需要进一步调查.
研究的目的:
- 评估不同年龄组和性别LFTs的时间趋势.
- 检查LFTs和肥胖的人类测量测量之间的横截面和纵向关联.
主要方法:
- 分析了来自5171名参与者 (35-75岁) 的数据,这些参与者来自前性基于人口的队列 (CoLaus SajaPsyCoLaus研究),随访时间为2019-2023.
- 利用了各种人类测量方法,包括BMI,腰与身高的比,以及相对脂肪质量.
- 采用多个线性回归和多层混合模型来分析关联,调整多个共变量.
主要成果:
- 在不同年龄组和性别中观察到LFT的明显时间变化.
- 肥胖性标志物在横截面和纵向分析中显示出与所有四个LFT具有显著 (p<0.001) 和强大的关联.
- 即使对多个混变量进行调整后,这些关联仍然存在.
结论:
- 在以人口为基础的队列中,LFTs表现出受年龄和性别影响的动态变化.
- 肥胖标志物与LFT变化独立相关,这强调了LFT解释中的身体组成的临床意义.
- 解释LFT结果需要考虑患者的临床背景,特别是在超重或肥胖方面.
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