半曲流氨酸A和B,来自ascomycete真菌Alternaria sp的类
Peinan Fu1, Xi Ren1, Qiaoling Wang1
1School of Pharmacy, Jiangsu Food and Pharmaceutical Science College Huaian 223003 People's Republic of China lvpharm@163.com.
RSC advances
|February 9, 2026
概括
从真菌中分离出了两种新型的宏化物,Penicurvularins A和B. 这些化合物对水生细菌和癌症细胞系表现出活性,突出显示了它们潜在的治疗应用.
科学领域:
- 自然产品 化学 化学
- 菌类学 菌类学是指菌类学.
- 药用化学 医学化学
背景情况:
- 菌代谢物是新生物活性化合物的丰富来源.
- 众所周知,Alternaria物种可以产生各种具有潜在药理活动的二次代谢物.
研究的目的:
- 从Alternaria sp.中分离和描述新的类化合物.
- 评估分离化合物的抗菌和细胞毒性活动.
主要方法:
- 使用色谱技术分离化合物.
- 使用核磁共振 (NMR) 光谱学阐明结构.
- 通过电子循环二元化 (ECD) 计算来确定绝对配置.
- 对抗菌活性进行最小抑制度 (MIC) 测定.
- 对各种瘤细胞系进行细胞毒性测定.
主要成果:
- 确定了两种新的类物质,Penicurvularins A (1) 和B (2),以及三种已知的化合物.
- 曲流氨酸A (1) 和化合物5对菌Alginolyticus和V. harveyi.表现出活性.
- 化合物5对Huh7,786-O和5673种瘤细胞系表现出显著的细胞毒性.
结论:
- 半曲流素A和B代表了来自Alternaria sp.的新型宏体结构.
- 隔离的化合物,特别是penicurvularin A和化合物5,具有有前途的抗菌和细胞毒性.
- 对这些化合物的进一步研究可能会导致开发新的治疗剂.
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