在患有自闭症谱系障碍的儿童中循环甲状腺激素和代谢物
Michael Hancock1, Rui Zhang2, Suzanne J Brown1
1Department of Endocrinology & Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Frontiers in endocrinology
|February 9, 2026
概括
甲状腺激素水平,包括自由甲状腺素 (FT4) 和自由三甲状腺素 (FT3),与非自闭症儿童相比,自闭症儿童的水平发生变化. 这项研究强调了在自闭症谱系障碍中甲状腺激素代谢的差异.
科学领域:
- 神经内分泌学神经内分泌学
- 代谢学 代谢学 代谢学
- 自闭症谱系障碍研究研究
背景情况:
- 甲状腺激素对神经系统的发育和功能至关重要.
- 在患有自闭症谱系障碍 (ASD) 的人群中,甲状腺激素和代谢物概况的研究有限.
研究的目的:
- 在被诊断为自闭症的儿童中调查和描述甲状腺功能和新陈代谢.
- 为了比较自闭症和非自闭症儿童之间的甲状腺激素和代谢物水平.
主要方法:
- 一项涉及788名自闭症儿童和301名非自闭症儿童 (包括兄弟姐妹) 的横截面研究.
- 血甲状腺刺激激素 (TSH),自由T4 (FT4) 和自由T3 (FT3) 用自动免疫测试进行测量.
- 总T4,总T3和甲状腺激素代谢物用液体染色学-并联质谱法 (LCMS/MS) 量化.
主要成果:
- 与非自闭症儿童相比,自闭症儿童的自由T4 (FT4) 和自由T3 (FT3) 度明显较低.
- 在自闭症儿童中观察到总T4和总T3的较低水平.
- 特定的甲状腺激素代谢物3,5-T2和3,3'-T2在自闭症儿童中明显较低,而T0水平更高.
结论:
- 在自闭症和非自闭症儿童之间,循环甲状腺激素和代谢物配置不同,尽管差异很微妙.
- 这些发现强调了先进技术的实用性,如LCMS/MS用于详细的甲状腺激素经济分析.
- 这项研究提供了关于自闭症谱系障碍潜在的甲状腺相关因素的见解.
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