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在线自适应性放射治疗工作流程的质量保证,使用3D打印胸部人形幻影中的薄膜剂量测量
Daan Hoffmans1,2, Koen Nelissen1,2, Eva Versteijne1,2
1Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Radiation Oncology, De Boelelaan 1117, Amsterdam, the Netherlands.
Physics and imaging in radiation oncology
|February 9, 2026
概括
在线适应性放射治疗 (oART) 的质量保证通过使用3D打印的幻影得到了改善. 这项研究证实了oART的准确性,即使有解剖学变化,确保安全和稳健的治疗.
科学领域:
- 医学物理 医学物理
- 放射治疗技术 放射治疗技术
- 医疗成像医学成像
背景情况:
- 在线适应性放射治疗 (oART) 的质量保证由于商业幻影的局限性而存在挑战.
- 现有的幽灵往往缺乏解剖学代表性,无法进行准确的测试.
研究的目的:
- 调查形束计算断层扫描 (CBCT) 引导的oART在息和乳腺癌试验中的准确性.
- 为了评估3D打印的胸部人形幻影对oART质量保证的有效性.
主要方法:
- 开发了一个定制的3D打印的人形胸部幻影,结合了脊柱,乳房,心脏和肺部等解剖结构.
- 对脊柱和乳腺治疗计划进行了剂量测量,模拟了治疗变化.
- 测量结果与使用计划CT (pCT) 和合成CT (sCT) 与马分析 (4%/2毫米标准) 的计算剂量进行了比较.
主要成果:
- 位置和目标体积变化在pCT和sCT之间的马分析中没有显著差异 (p=0.15),表明工作流是稳定的.
- 极端变异显示了pCT和sCT马分析之间的边界显著差异 (p=0.051).
- 所有通过率都超过95%,除了由于sCT密度错误造成的小例外.
结论:
- 在3D打印的幻影中使用膜测量开发的质量保证方法有效验证了oART的准确性.
- 这种方法在治疗期间处理解剖学偏差方面表现出强大.
- 定制的幻影作为oART质量保证的适当的端到端测试.
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