在接受辅助生殖技术的患者中,进行孕激素初级卵巢刺激方案
Shanqin Qi1, Haiyan Yu1,2, Xiaojing Yang1,3
1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Frontiers in reproductive health
|February 9, 2026
概括
孕激素辅助卵巢刺激 (PPOS) 方案是IVF/ICSI-ET中受控卵巢过度刺激的安全有效替代方案. 它提供了与OHSS风险较低的可比妊娠结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
- 在体外受精过程中受精.
背景情况:
- 控制性卵巢高刺激 (COH) 是辅助生殖技术 (ART) 的一个关键组成部分.
- 传统的COH协议旨在优化卵细胞产量,同时最大限度地降低卵巢过度刺激综合征 (OHSS) 等风险.
- 孕激素主导的卵巢刺激 (PPOS) 协议作为一种新的COH治疗方法而出现.
研究的目的:
- 评估新的孕激素主导卵巢刺激 (PPOS) 协议的有效性和安全性.
- 在接受体外受精/细胞内精子注射和胚胎移植 (IVF/ICSI-ET) 的患者中,将PPOS与传统疗法进行比较.
主要方法:
- 自2015年以来,对PPOS协议发表的研究进行系统审查和分析.
- 卵巢刺激特征,胚胎特征,怀孕率和新生儿结果的比较.
- 对PPOS协议与传统ART协议的优点和局限性的评估.
主要成果:
- PPOS提供了对黄素化激素激增和自发排卵的强有力的控制,增强了卵细胞的成熟和恢复.
- PPOS实现了有前途的临床怀孕率,与传统协议相比.
- PPOS表现出相当于出生缺陷和先天性形的比例,OHSS的风险明显较低.
结论:
- PPOS协议是ART的合适替代方案,提供非劣质或可比的结果.
- PPOS对卵细胞发育和胚胎质量没有不利影响.
- PPOS提供了有利的安全概况,特别是在OHSS风险方面.
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