Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.6K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.6K
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

1.7K
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
1.7K
What is the Immune System?01:38

What is the Immune System?

131.2K
Overview
131.2K
Humoral Immune Responses01:36

Humoral Immune Responses

84.1K
Overview
84.1K
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

2.0K
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
2.0K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

995
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
995

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Impact of non-selective beta-blockers on acute kidney injury outcomes in patients with decompensated cirrhosis.

Journal of hepatology·2026
Same author

Human vaccine responses regulated by parallel cytokine pathways.

Nature immunology·2026
Same author

Aging restricts maturation of CXCL13<sup>+</sup> T follicular helper cells in human immunity.

Cell reports·2026
Same author

Automated Computed Tomography-based Liver Steatosis Risk Stratification of Deceased Organ Donors Using Real-world Data.

Transplantation·2026
Same author

Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery.

Nature biotechnology·2026
Same author

Aging restricts maturation of CXCL13<sup>+</sup> T follicular helper cells in human immunity.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Feb 10, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K

通过向的TGF-β激动剂选择性免疫沉默.

Qinli Sun, Masato Ogishi, Hua Jiang

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    向的TGF-β激动剂选择性地使病原性T和B细胞沉默,为自身免疫和炎症性疾病提供了有前途的新疗法,并提高了安全性和有效性.

    更多相关视频

    Studying TGF-&#946; Signaling and TGF-&#946;-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
    06:54

    Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

    Published on: October 27, 2020

    14.5K
    Spheroid Assay to Measure TGF-&#946;-induced Invasion
    09:18

    Spheroid Assay to Measure TGF-β-induced Invasion

    Published on: November 16, 2011

    22.5K

    相关实验视频

    Last Updated: Feb 10, 2026

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
    10:44

    In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

    Published on: May 5, 2023

    1.9K
    Studying TGF-&#946; Signaling and TGF-&#946;-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
    06:54

    Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

    Published on: October 27, 2020

    14.5K
    Spheroid Assay to Measure TGF-&#946;-induced Invasion
    09:18

    Spheroid Assay to Measure TGF-β-induced Invasion

    Published on: November 16, 2011

    22.5K

    科学领域:

    • 免疫学 免疫学 免疫学
    • 细胞生物学 细胞生物学
    • 药物发现 药物发现 药物发现

    背景情况:

    • 目前用于免疫疾病的疗法耗尽T细胞和B细胞,但具有包括不良事件和复发在内的局限性.
    • 转化生长因子β (TGF-β) 具有免疫抑制性质,可以用于治疗益处.

    研究的目的:

    • 开发一种新的治疗策略,使用向的TGF-β激动剂来选择性地沉默致病性T细胞和B细胞.
    • 在临床前模型中评估细胞选择性TGF-β激素的疗效和安全性.

    主要方法:

    • 开发虫衍生TGF-β模仿激素剂,针对特定的T细胞 (CD4,CD8) 和B细胞 (CD19) 种群.
    • 在小鼠和人类脏器官中评估T细胞激活和扩张.
    • 评估人类脏器官中的抗体反应和B细胞分化.
    • 在免疫性疾病的小鼠模型中测试细胞类型特定的TGF-β激动剂.

    主要成果:

    • 针对T细胞的TGF-βagonists有效地抑制了抗原刺激的T细胞激活和扩张.
    • 针对CD4 T细胞的激动剂将T细胞重新编程为静止或调节性表型,沉默抗体反应.
    • CD19 B 细胞向激素破坏了 B 细胞分化到抗体分泌细胞的过程.
    • 细胞选择性TGF-β激动剂在小鼠模型中改善了疾病活性,具有最小的脱效应.

    结论:

    • 细胞选择性TGF-β激动体是一种多功能治疗策略,用于精确的免疫功能沉默.
    • 这种方法为治疗免疫性疾病提供了广泛免疫细胞枯竭的有希望的替代方案.