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Updated: Feb 10, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Published on: February 25, 2022

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病态的TDP-43丝在突触处积聚,导致突触功能障碍.

Renren Chen, Imogen Stockwell, Jessica C Pierce

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    在FTD等神经退行性疾病的早期,TDP-43蛋白聚合物在突触中积聚,导致突触功能障碍和神经元过激动. 这项研究将TDP-43光纤积累与疾病进展和神经元损失联系起来.

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