Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Structure and Organization of Smooth Muscles01:13

Structure and Organization of Smooth Muscles

8.8K
Smooth muscle tissue is a type of muscle tissue that can be found lining various vital organs in the human body, including the lungs, blood vessels, digestive tract, and respiratory tract. This type of tissue is responsible for regulating the movements of these organs, playing crucial roles in the functioning of various systems, including the vascular, digestive, respiratory, and urinary systems.
Structure of smooth muscle cell
Smooth muscle cells are spindle-shaped with tapering ends and a...
8.8K
Functions of Smooth Muscles01:23

Functions of Smooth Muscles

3.5K
Smooth muscles are an important type of muscle tissue that plays a vital role in the involuntary movements of internal organs. For example, they help regulate the movement of food through the gut and the flow of blood through the circulatory system.
Function of visceral smooth muscles
Visceral smooth muscle is found in the walls of all hollow organs, except the heart, and is a key player in the involuntary movements that drive the functioning of these internal organs. This tissue is arranged in...
3.5K
Smooth Muscle Contraction01:25

Smooth Muscle Contraction

7.9K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
7.9K
Organization of the Brain01:30

Organization of the Brain

2.7K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.7K
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

59.6K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.6K
Energy to Drive Translocation01:37

Energy to Drive Translocation

2.9K
Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
2.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

FALCON: Closed-Loop Multi-Objective Optimization of Lipid Nanoparticles for Cell-Selective mRNA Delivery.

bioRxiv : the preprint server for biology·2026
Same author

Comparison of brain normalization software and lesion compensation techniques in chronic perinatal stroke imaging.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Using Data to Drive Policy Action: An Urgent Call for Funding Interdisciplinary Team-Based Rheumatology Care.

Healthcare quarterly (Toronto, Ont.)·2026
Same author

Retraction Note: Surface modification minimizes the toxicity of silver nanoparticles: an in vitro and in vivo study.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2026
Same author

Spontaneous cortical vasodynamics form a multiscale propagation architecture in the awake brain.

bioRxiv : the preprint server for biology·2026
Same author

Immigration Status and Time to Accessing Publicly Funded Flash Glucose Monitoring Systems.

JAMA network open·2026

相关实验视频

Updated: Feb 10, 2026

Focal Ca2+ Transient Detection in Smooth Muscle
17:41

Focal Ca2+ Transient Detection in Smooth Muscle

Published on: June 29, 2009

11.7K

滑动肌肉功能障碍导致脑血管储备衰竭和末端器官脑损伤.

Takahiko Imai, Vijai Krishnan, James H Lai

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    ACTA2基因突变会损害大脑血管储备,导致大脑血流减少,大脑易受低输血的影响. 这种血管光滑肌肉功能障碍会导致损伤,这凸显了保持脑血管储备的重要性.

    更多相关视频

    Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
    06:14

    Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

    Published on: June 11, 2017

    8.8K
    Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
    04:29

    Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

    Published on: May 17, 2024

    1.2K

    相关实验视频

    Last Updated: Feb 10, 2026

    Focal Ca2+ Transient Detection in Smooth Muscle
    17:41

    Focal Ca2+ Transient Detection in Smooth Muscle

    Published on: June 29, 2009

    11.7K
    Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
    06:14

    Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

    Published on: June 11, 2017

    8.8K
    Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
    04:29

    Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

    Published on: May 17, 2024

    1.2K

    科学领域:

    • 神经学 神经学
    • 血管生物学 血管生物学
    • 遗传学 遗传学 是一个

    背景情况:

    • 脑血管储备缺陷是缺血脆弱性的关键.
    • 将血管光滑肌功能障碍与脑损伤联系在一起的机制尚不清楚.
    • ACTA2突变导致多系统平滑肌肉功能障碍.

    研究的目的:

    • 为了确定病原性ACTA2突变是否导致基线脑血管储备衰竭.
    • 在没有动脉堵塞的情况下,评估大脑对低 perfusion 的脆弱性.

    主要方法:

    • 在ACTA2突变的小鼠模型中检查了脑血管结构,血液动力学和储备.
    • 通过血管学评估大脑动脉形态.
    • 在血管活性挑战和低血压期间测量血压反应性和脑血流 (CBF).
    • 通过组织学,功能连接成像和行为测试评估下游大脑效应.

    主要成果:

    • 滑动肌肉收缩能力受损导致大脑动脉狭窄,血管活性降低.
    • 突变小鼠显示脑血管储备减弱,基线CBF减少.
    • 低血压和压力损害了补偿性输液,恶化了行为结果,并导致大脑损伤 (白质损失,神经元损失).

    结论:

    • ACTA2突变导致基线脑血管储备衰竭,增加大脑对低 perfusion 和缺血损伤的脆弱性.
    • 这确立了储备衰竭作为一种机制,将血管功能障碍与脑损伤联系起来.
    • 保持脑血管储备对于低血压倾向的血管疾病中大脑健康至关重要.