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Updated: Feb 10, 2026

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
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Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing

Published on: January 20, 2023

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快速的受体内化增强了针对CD7的脂质纳米颗粒,以有效地将mRNA传递给T细胞,并在体内进行CART细胞工程

Jianhao Zeng, Tyler Ellis Papp, Awurama Akyianu

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    向性脂质纳米颗粒 (tLNPs) 有效地将mRNA传递给T细胞,用于体内化学抗原受体 (CAR) T细胞的生成. 针对CD7的TLNP表现出卓越的性能,由受体内部化驱动,而不是丰富性.

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