相关实验视频
Updated: Feb 10, 2026

10:20
Single-cell Profiling of Developing and Mature Retinal Neurons
Published on: April 19, 2012
14.7K
一个单细胞和空间的3D多原子地图,关于人类基底和抑制性神经元的发展
bioRxiv : the preprint server for biology
|February 9, 2026
概括
这项研究揭示了在人类基底腺节发育过程中的3D基因组和表观基因组变化. 它确定基因调节网络对于中等脊髓神经元发育至关重要,并将它们与神经精神疾病风险联系起来.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 基因组学就是基因组学.
背景情况:
- 人类的基底 (BG) 对于运动和认知功能至关重要,它们是从短暂的胚胎结构中发展起来的,称为突发体 (GE).
- 了解GE发育和随后的神经元成熟的表观基因组和3D基因组调节对于破译大脑发育和疾病至关重要.
研究的目的:
- 阐明人类大脑中GE和GE衍生神经元的规范和成熟过程中的表观基因组和3D-基因组动态.
- 确定管理特定基底细胞细胞类型,如中等状神经元 (MSN) 的发展的监管程序.
- 研究MSN中的基因调节区域与神经精神疾病遗传风险之间的关系.
主要方法:
- 单核甲基-3C测序 (snm3C-seq) 用于联合表观基因组和3D基因组分析.
- 高复杂空间转录组学用于绘制发育中的大脑组织中的基因表达.
- 染色体和RNA单分子成像用于调节元素的高分辨率分析.
主要成果:
- 在孕期和婴儿期,在GE次区域 (LGE和CGE) 展示了异质的发育轨迹.
- 确定了MSN亚型规范的基础上的同步3D表观基因组成熟.
- 在婴儿大脑中,在神经元和寡细胞原生体分化过程中观察到3D基因组构造的短暂重塑.
- 在与神经精神疾病风险相关的区域发现MSN活性调节位点的丰富.
结论:
- 这项研究描绘了围产期人类腹腔前代和基底细胞群体中复杂的,特定于血统的3D基因组动态.
- 研究结果提供了对人类基底腺节发育的调节机制的见解,并提供了与神经精神疾病病因学的潜在联系.
相关概念视频
Laminins are the Adhesive Proteins of Basal Lamina
3.3K
Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
3.3K
Basal Lamina are the Specialized Form of ECM
3.9K
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Proteins...
3.9K
Type IV Collagen of Basal Lamina
3.1K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
A type IV collagen molecule has six alpha chains which can...
3.1K
Excitatory and Inhibitory Effects of Neurotransmitters
13.1K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
13.1K
Sustainable Development
15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Multi-input and Multi-variable systems
427
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
In the absence of...
427

