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Updated: Feb 10, 2026

Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells
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Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells

Published on: June 16, 2017

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通过SS18::SSX进行BAF复合体独立基因激活:

Afroditi Sotiriou, Jinxiu Li, Sanya Middha

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    这项研究表明,突肉瘤中的致癌性SS18::SSX融合蛋白可以独立于BAF复合体驱动转录. 针对EP300等联合激活剂为融合驱动的癌症提供了新的治疗策略.

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