相关实验视频
Updated: Feb 10, 2026

09:25
Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
Published on: June 28, 2013
27.6K
饮食脂肪含量影响小鼠的泛IN进展和胰腺癌发展
bioRxiv : the preprint server for biology
|February 9, 2026
概括
性饮食 (KD) 在早期胰腺癌的小鼠模型中显著缩短了生存期,加速了瘤的进展,并促进了攻击性,侵入性癌症类型. 这凸显了对高风险人群中KD的谨慎需要.
科学领域:
- 在瘤学瘤学.
- 代谢研究研究 代谢研究
- 癌症生物学 癌症生物学
背景情况:
- 饮食中的宏观营养素会影响胰腺癌的发展.
- 性饮食 (KD) 对早期胰腺癌的影响尚不清楚.
- 研究高脂饮食对Kras驱动的胰腺瘤的影响至关重要.
研究的目的:
- 确定食脂质如何影响Kras驱动的胰腺癌的发病和进展.
- 在小鼠模型中比较低脂肪饮食 (LFD),高脂肪饮食 (HFD) 和KD的影响.
主要方法:
- 使用了Ptf1aCreERT2;KrasG12V (AcinarKrasG12V) 的小鼠模型.
- 管理的LFD,HFD和KD饮食.
- 评估的生存率,葡萄糖耐受性,β-基酸盐水平,瘤组织学,蛋白质组信号通路 (PI3K-Akt-mTOR,EGFR),以及血清细胞因子/化学因子概况.
主要成果:
- 与标准饮食 (SD) (87天) 和LFD (57天) 相比,KD显著降低了生存期 (26天).
- 此外,HFD还降低了存活率 (35天) 与SD相比.
- 肯德基诱导的葡萄糖不耐受性和升高的β-基酸盐;KD和HFD都促进了具有纤维化和 stromal CD39表达的侵略性PDAC,激活PI3K-Akt-mTOR/EGFR信号传递,并诱导了亲炎症/亲血管生环境.
结论:
- 饮食中的脂质丰富,特别是KD,加速了由瘤性Kras.驱动的早期胰腺瘤.
- 这些饮食促进了有利于瘤的微环境.
- 建议在胰腺癌风险较高的人群中使用KD时谨慎使用.
相关概念视频
mTOR Signaling and Cancer Progression
4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.9K
Dietary Connections
62.1K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
62.1K
Proteins: Dietary Sources and Requirements
1.8K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.8K
Stereotype Content Model
15.5K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.5K
Carbohydrates: Dietary Sources and Requirements
1.8K
Carbohydrates are predominantly obtained from plant sources. With the exception of lactose found in milk and insignificant glycogen amounts in meat, most consumed carbohydrates have plant origins. Monosaccharides and disaccharides, or sugars, can be sourced from fruits, honey, milk, sugar cane, and sugar beets. Grains and vegetables are rich in the polysaccharide starch. Two types of polysaccharides provide fiber: cellulose, which is abundant in many vegetables, forms undigestible roughage or...
1.8K
Lipids: Dietary Sources and Requirements
2.2K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.2K

