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Updated: Feb 10, 2026

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
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C端CD28酸化 (Y218) 调节了CAR-T细胞的IL-2分泌和抗瘤作用

Elena Martinez-Planes, Maria Cecilia Ramello, Miguel G Fontela

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    在CAR-T细胞疗法中,CD28协同刺激至关重要. 这项研究确定Y218酸化对CAR-T细胞功能和抗瘤疗效至关重要,为增强CAR信号提供了一个新的策略.

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