一种高发酵纤维的西方饮食降低了醇水平
bioRxiv : the preprint server for biology
|February 9, 2026
概括
西方饮食破坏了肠道细菌和新陈代谢. 食纤维补充剂可以通过恢复微生物平衡和减少有害代谢物来减轻这些负面影响,促进更好的肠道健康.
科学领域:
- 微生物学 微生物学
- 代谢科学 代谢科学
- 营养科学 营养科学
背景情况:
- 饮食显著影响肠道微生物群的组成和宿主健康.
- 西方饮食 (WD) 与肠道失调和代谢疾病风险增加有关.
- 食纤维补充剂可以抵消WD引起的负面影响.
研究的目的:
- 研究WD对小鼠肠道微生物群和宿主新陈代谢的影响.
- 探索食纤维补充剂 (果实糖,瓜尔,乳酸) 的潜力,以减轻WD诱导的变化.
- 分析对肠道微生物多样性,肠道代谢产物和宿主基因/蛋白质表达的影响.
主要方法:
- 在19周的时间里,小鼠被食了对照,WD或WD,并补充了可发酵纤维 (FF).
- 分析包括CECAL元基因组学 (全基因组猎枪测序).
- 进行了代谢分析 (LC-MS/MS),以及组织基因/蛋白质表达 (RT-PCR,免疫阻塞).
主要成果:
- WD引发了代谢障碍,减少了肠道微生物的多样性,改变了托代谢.
- WD增加了内醇水平和Cyp2e1表达,与氧化应激和肠道屏障功能障碍有关.
- 纤维补充剂 (除了用于硫酸乙的瓜尔) 改善了代谢参数,增加了有益代谢物 (SCFA,酸乙) 和减少了硫酸乙.
结论:
- WD 破坏了肠道微生物群的甲酸代谢,可能是通过失衡甲酸生产和利用细菌.
- 食纤维补充剂通过减轻这种微生物失衡提供保护作用.
- 纤维的好处包括改善肠道健康标志物和减少代谢功能障碍.
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