代谢建模和功能基因组学揭示了结直肠癌中的种群和宿主基因相互作用
bioRxiv : the preprint server for biology
|February 9, 2026
概括
大肠直肠癌 (CRC) 涉及宿主细胞和肠道微生物群的代谢变化. 瘤代谢创造了一个有利于某些微生物的环境,然后通过代谢相互作用促进癌症的进展.
科学领域:
- 微生物学 微生物学
- 代谢工程是代谢工程.
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 与瘤微环境微生物群落的改变有关.
- 宿主细胞代谢重编程是CRC的关键,但微生物代谢变化仍然不太了解.
- 调查这些微生物代谢变化对于理解CRC病变发生至关重要.
研究的目的:
- 研究结直肠癌中的代谢宿主微生物群相互作用.
- 了解微生物代谢变化如何促进CRC的发展.
- 探索瘤代谢重编程在塑造微生物组中的作用.
主要方法:
- 在三个数据集中使用了特定于患者的in silico代谢模型.
- 集成的代谢预测与宿主转录组学数据.
- 进行了in silico spent medium实验和体外结肠癌细胞测定与人类微生物组.
主要成果:
- 杆菌在与瘤相关的微生物组中表现出更快的增长.
- 确定了瘤基因表达与CRC相关的种群生长 (Porphyromonadaceae,Blautia,Streptococcus) 之间的相关性.
- 证明了Blautia在瘤细胞代谢物上的优先生长,并确定了宿主基因表达的变化,以应对特定的微生物在体外.
结论:
- 揭示了结直肠癌中宿主和微生物群之间的代谢对话.
- 瘤代谢重编程为致病微生物创造了一个有利的利基.
- 微生物代谢交叉可能会加强CRC中的瘤发生过程.
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