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Updated: May 16, 2026

Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells
11:35

Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells

Published on: June 16, 2017

化学控制2'-基基依赖的Cas9目标激活使CRISPR RNA核糖替代成为可能

Adrian A Pater, Halle M Barber, Sruthi Sudhakar

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    化学修饰的CRISPRRNAs (crRNAs) 增强了基于CRISPR的疗法. 研究人员发现,特定的核糖组对于Cas9结合至关重要,使得完全稳定,核酶耐药的crRNA可以用于改进的基因编辑药物.

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