揭开免疫检查点生物学的AMPK和BET调节:对个性化医学的影响

相关实验视频

Updated: Feb 10, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.1K

Christina S Ennis, Kunlin Huang, Allison N Casey

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    患有2型糖尿病 (T2D) 的三阴性乳腺癌 (TNBC) 患者的治疗结果较差. 基因和超终端域 (BET) 蛋白质和5'腺氨酸单酸激活蛋白激酶 (AMPK) 影响免疫检查点,可能改善T2DTNBC的免疫疗法.

    更多相关视频

    Study of the DNA Damage Checkpoint using Xenopus Egg Extracts10:55

    Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

    Published on: November 5, 2012

    17.1K
    Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM1010:42

    Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

    Published on: November 19, 2016

    8.0K

    相关概念视频

    Combination Therapies and Personalized Medicine02:50

    Combination Therapies and Personalized Medicine

    Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
    The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
    6.2K
    The Spindle Assembly Checkpoint02:19

    The Spindle Assembly Checkpoint

    The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
    Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
    3.9K
    What is Conservation Biology?01:57

    What is Conservation Biology?

    Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
    24.4K
    What is the Immune System?01:38

    What is the Immune System?

    Overview
    131.2K
    Epigenetic Regulation01:46

    Epigenetic Regulation

    Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
    33.9K
    GTPases and their Regulation02:14

    GTPases and their Regulation

    Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
    Large G-proteins,...
    9.9K