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Updated: Feb 10, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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在TAD边界,H4K20me3和CTCF相互作用,调节细胞状态转换

Kaiser Atai, Mithun Mitra, Eliana Bohn

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    基斯顿修饰H4K20me3和CTCF蛋白在调节细胞增殖和静止方面具有相反的作用. 它们在染色体边界元素的竞争控制了细胞状态转换,影响了基因调节和细胞结构.

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