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Updated: Feb 10, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

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在SETD1A功能丧失小鼠模型中,在空间工作记忆任务执行期间,改变了thalamo-prefrontal同步动态,该模型具有精神分裂症倾向

Sofiya Hupalo, David A Kupferschmidt, Ako Ikegami

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    在SETD1A的遗传突变损害了小鼠的工作记忆电路,为精神分裂症风险提供了洞察力. 这项研究揭示了与SETD1A哈普洛缺陷相关的特定神经同步缺陷,这是神经发育障碍的关键因素.

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