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Updated: Feb 10, 2026

Rapid Identification of Chemical Genetic Interactions in Saccharomyces cerevisiae
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一个化学-遗传相互作用矩阵揭示了药物机制和遗传结构

Jasmin Coulombe-Huntington, Thierry Bertomeu, Caroline Huard

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    研究人员利用全基因组的CRISPR屏幕对310种药物进行了人类细胞遗传的映射. 这揭示了成千上万的化学遗传相互作用 (CGI),揭示了新药作用机制和药物发现的遗传洞察力.

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