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Updated: Feb 10, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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IGF1的目标是雷特综合征天体细胞降解IGF结合蛋白,拯救突触生成并恢复线粒体功能

Prachi Ojha, Velina Kozareva, Alexandria Barlowe

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    雷特综合征涉及天体细胞功能障碍,其中高的IGFBP2会影响突触形成. 一个IGF1-衍生降低IGFBP2,恢复突触功能,并为这种神经发育障碍提供治疗策略.

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