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Updated: Feb 10, 2026

A Patient-Derived Xenograft Model for Venous Malformation
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在小鼠发育过程中,TIE2 p.L914F的构成性,马赛克表达会导致静脉形的形成

Lindsay J Bischoff, Chhiring Sherpa, Sandra Schrenk

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    在小鼠中,TIE2 p.L914F突变的马赛克表达导致部分胚胎致死性和静脉形 (VM). 这项研究建立了一个新的体内模型,用于研究突变TIE2驱动VM疾病.

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