使用基于VMAT的SBRT在DIBH场景下优化不可操作的早期中心位置的非小细胞肺癌的小型计划:单弧模型或双弧计划?
Yangyang Huang1,2, Jinjin Yuan1, Alan Chu1
1Department of Radiotherapy, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in oncology
|February 9, 2026
概括
单弧VMAT显著减少了非小细胞肺癌患者的立体体辐射疗法的光束启动时间,提高了治疗效率,而不会影响计划质量.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 胸部瘤学 胸部瘤学
背景情况:
- 立体体射线疗法 (SBRT) 是早期非小细胞肺癌 (NSCLC) 的关键治疗方法.
- 位于中心的瘤和患者因子,如不可操作性,需要先进的技术.
- 深呼吸呼吸 (DIBH) 对于最大限度地减少肺部SBRT中的运动至关重要.
研究的目的:
- 为了比较单弧 (SA) 和双弧 (DA) 的VMAT技术用于SBRT在位于中心的NSCLC中.
- 分析剂量计参数,计划复杂性和光束上线时间 (BOT).
- 在DIBH条件下评估SA-VMAT的疗效.
主要方法:
- 在DIBH中,对24例NSCLC病例进行了SBRT治疗的回顾性分析.
- 将重新设计的SA-VMAT计划与原来的DA-VMAT计划进行比较.
- 评估PTV/GTV覆盖范围,OAR节省,计划复杂性 (分段,MU),GPR和BOT.
主要成果:
- 与DA计划相比,SA计划的PTV覆盖率更高 (D98%,D2%,HI) (p < 0.05).与DA计划相比,SA计划的PTV覆盖率更高 (D98%,D2%,HI).
- 在SA计划中,计划的复杂性减少了 (18.82%的细分,8.15%的MU;p < 0.001).
- 与SA计划相比,平均BOT显著减少了19.70% (p < 0.001),与可比的GPR相比.
结论:
- 单弧VMAT在DIBH下为NSCLC SBRT提供了显著的BOT降低.
- SA计划保持可比的计划质量并提高患者的舒适性.
- 需要对更大的队列进行进一步的研究,以确认长期的临床结果.
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