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年轻成年人的累积脂质暴露和中年风险 MASLD
Yun Chen1, Yinan Zheng2, Longgang Zhao1
1Yale School of Nursing, Yale University, Orange, CT, USA.
JHEP reports : innovation in hepatology
|February 9, 2026
概括
在年轻成年期保持最佳的脂质水平对于预防与代谢功能障碍相关的脂肪性肝病 (MASLD) 至关重要. 累积的异常脂质暴露显著增加中年MASLD风险,部分由DNA甲基化介导.
科学领域:
- 心血管健康 心血管健康
- 肝病学 肝病学是一种肝病学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 年轻成年人脂质样本与中年代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的联系尚不清楚.
- 脱脂症是MASLD的一个关键可修改的风险因素,但研究往往忽略了从早期成年期开始的长期累积影响.
研究的目的:
- 调查年轻人的脂质样本与中年发展MASLD的风险之间的联系.
- 检查表观遗传学生物标志物的作用,特别是DNA甲基化,作为这种关系中的调解者.
主要方法:
- 利用了257名参与者在25年内在年轻成年人中冠状动脉风险发展研究中的数据.
- 从18-39岁计算的时间加权平均 (TWA) 脂质水平,并在50岁时使用CT扫描评估MASLD.
- 分析了参与者的血液DNA中超过84万个部位的DNA甲基化.
主要成果:
- 在年轻成年期,异常的甘油三,高密度胆固醇,非高密度胆固醇,ApoB,低密度胆固醇和总胆固醇水平与中年期的MASLD风险增加有显著的关联.
- 与最佳水平相比,对于各种脂质异常,MASLD的几率比率从1.39到3.26不等.
- 在CPT1A,ABCG1和DHCR24基因中的DNA甲基化标记部分介导了脂质和MASLD之间的观察到的关联的2.9%-15.4%.
结论:
- 在年轻成年期对不利的脂质样本的累积暴露是中年MASLD的重要预测因素.
- 脂质相关的DNA甲基化部分解释了从生命早期的脂质不良症到MASLD发展的途径.
- 在年轻成年期评估累积脂质暴露可以改善MASLD风险分层,并为预防策略提供信息.
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