奇托寡糖在自然衰老中的微生物群-代谢物-免疫轴上的影响
Wei Liu1, Pengcheng Shi1, Yunyu Xiao2
1Zhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Frontiers in nutrition
|February 9, 2026
概括
在老年小鼠中补充奇托寡糖化物 (COS) 改变了肠道细菌的形状,促进了像Muribaculaceae这样的有益微生物,并改变了代谢物. 这种干预也减少了炎症和细胞衰老标志物,这表明有可能减轻衰老的影响.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 自然衰老的特点是肠道失调,代谢变化和慢性轻度炎症.
- 素寡糖 (COS) 对这些与衰老相关的变化的影响,特别是微生物群-代谢物-免疫相互作用,尚不清楚.
研究的目的:
- 为了研究长期COS补充剂对肠道微生物群,血清代谢,免疫标记物和自然衰老小鼠的衰老信号的影响.
主要方法:
- 长度研究涉及年轻和老年雄性C57BL/6J小鼠,补充了COS.
- 分析包括16S rRNA测序,非向血清代谢量,多重细胞因子测量和p53和p21的免疫组织化学.
主要成果:
- 补充COS改变了肠道微生物群的组成,减少了Firmicutes,增加了Bacteroidota,并显著丰富了Muribaculaceae.
- 代谢分析显示了 propionate 和氨基酸通路的变化,与 Muribaculaceae 丰富度和特定的细胞因子相关.
- COS减轻了与年龄相关的体重增加,并在大脑和脏中减少了p53和p21的表达,表明衰老减少.
结论:
- 在老年小鼠中长期服用COS补充剂促进了与Muribaculaceae-propionate-immune轴相关的肠道微生物群概况的转变.
- 补充COS似乎可以减轻与年龄相关的炎症和细胞衰老,这表明对衰老有潜在的治疗益处.
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