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Updated: Feb 10, 2026

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一个新的Echinococcus ortleppi感染病例被通过下一代测序在中国诊断出来

Xishuai Jia¹, Junhua Tian¹, Ming Huang²

¹Wuhan Center for Disease Control and Prevention, Wuhan, Hubei, China.

Frontiers in cellular and infection microbiology

|February 9, 2026

概括

在中国使用下一代测序,发现了一种罕见的人类感染 Echinococcus ortleppi. 这一发现突显了这种寄生动物性 zoonosis 在非特有地区潜在的未被识别的传播途径.

科学领域:

动物传播疾病动物传播疾病
寄生虫学的寄生虫学
分子流行病学分子流行病学

背景情况:

囊性球菌病 (CE) 是一种具有显著的寄生动物性 zoonosis,具有相当大的人类发病率和死亡率.
在人类中,由 Echinococcus ortleppi 引起的感染非常罕见.
中国通常被认为是E. ortleppi. 的非流行地区.

研究的目的:

为了确定中国武汉的一例CE病例的致病因子.
鉴定E. ortleppi菌株的遗传构成的特征.
调查这种罕见的人类感染在非流行地区的影响.

主要方法:

在人类患者中诊断 cystic echinococcosis.
下一代测序 (NGS) 用于病原体识别.
整个线粒体基因组测序和比较分析.

主要成果:

中国武汉的一名27岁男性被诊断出患有CE.
美国国家基因学会证实病原体是Echinococcus ortleppi.
完整的线粒体序列显示了99.92%的同一性与来自日本牛的E. ortleppi菌株.
这是中国第三个报告的E. ortleppi人类病例.

结论:

该研究确定了E.ortleppi是中国非流行地区罕见CE病例的原因.
与日本牛品种的遗传相似性表明潜在的跨境传播或共享的,尚未识别的储库.
在中国可能存在未知的E. ortleppi传播途径,需要进一步的流行病学调查以确定和减轻风险.

关键词:

中国中国中国中国.埃奇诺科克 (Echinococcus ortleppi) 是一种虫.囊性埃奇诺科科科斯 (Cystic Echinococcosis) 是一种囊性埃奇诺科科斯.流行病学流行病学非特有地区的非特有地区.

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