一个不寻常的5 - 奥克索普罗林酸性酸化病例
Nils Müller1, Anne Krüger1, Alexander Reshetnik1
1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Berlin, Germany.
Kidney medicine
|February 9, 2026
概括
高剂量的克洛西林可以导致5-oxoproline酸化,这是一个罕见的情况. 这一案例突显了即使没有使用青的情况,也可能发生这种情况,这表明在接受高剂量青的患者中,它可能被低诊断.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床毒理学 临床毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢性酸化是常见的,但存在罕见的原因.
- 5-oxoproline (pyroglutamic acid) 的积累会导致高阴离子间隙的代谢酸化.
- 这通常与类醇 (乙氨基) 和克西林/西林或危险因素有关.
研究的目的:
- 报告一个5-oxoproline酸性病例.
- 为了调查它在没有使用青醇的情况下发生的情况.
- 建议在特定的临床场景中考虑这种诊断.
主要方法:
- 一个中年男性的病例报告.
- 对患者病史的分析,对青和风险因素进行分析.
- 高剂量流沙治疗的评估.
主要成果:
- 患者出现了高离子间隙代谢酸性化症.
- 这被归因于5-oxoproline的积累.
- 这位患者没有过使用青的病史,也没有显著的风险因素.
结论:
- 单独使用高剂量的克洛西林,也可能发生5-oxoproline酸症.
- 这种诊断应该考虑,即使没有暴露于类醇.
- 在接受高剂量克洛西林/西林治疗的患者中,这种情况可能被低诊断.
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