乳糖酸杂质对乳糖结晶的影响:作为有效的预处理,脱离离子化
Silvio Trespi1, Marco Mazzotti1
1Institute of Energy and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.
Crystal growth & design
|February 9, 2026
概括
在α-乳糖单水化合物中的乳糖酸杂质会影响结晶. 通过脱离离子化去除这些离子杂质,可以澄清它们对晶体形成和性质的影响.
科学领域:
- 食品科学 食品科学 食品科学
- 结晶科学 结晶科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 商用α-乳糖单酸盐含有微量乳糖酸盐杂质.
- 这些杂质可以影响α-乳糖单水合物的结晶过程.
研究的目的:
- 为了研究乳糖酸盐对α-乳糖单水合物结晶的作用.
- 开发一种量化乳糖酸盐度及其融入晶体的方法.
- 评估离子杂质对结晶动力学和晶体形态学的影响.
主要方法:
- 用不同的种子质量和超和度对α-乳糖单水化合物的实验性结晶.
- 一种新的pH测量技术来量化乳糖酸盐.
- 使用离子交换珠来脱离乳糖溶液的离子化.
主要成果:
- 使用pH值测量量乳糖酸盐度及其融入晶体的量化.
- 脱离离子有效地去除了乳糖酸盐,使得分析更加清晰.
- 离子杂质显著影响了结晶动力学和乳糖晶体的面积比.
结论:
- 乳糖酸盐杂质明显影响α-乳糖单水合物结晶.
- 脱离离子是用于受控结晶研究去除这些杂质的有效方法.
- 了解杂质的影响对于优化乳糖生产和质量至关重要.
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