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对瘤免疫微环境和甲状腺癌免疫疗法的新见解

Jia-Jia Du¹, Jian Wang¹, Kai Ma¹

¹Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.

Frontiers in immunology

|February 9, 2026

概括

甲状腺癌 (TC) 的发展受到其瘤微环境 (TME) 的影响. 了解TME相互作用为治疗耐药甲状腺癌提供了新的免疫治疗点.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

甲状腺癌 (TC) 是最常见的内分泌恶性瘤.
虽然许多TC病例的预后很好,但有些人表现出耐治疗性或侵略性行为.
瘤微环境 (TME) 显著影响TC发育和进展.

研究的目的:

研究甲状腺癌中瘤免疫微环境 (TiME) 中细胞和分子相互作用的复杂机制.
分析针对TC中的TiME组件的治疗潜力.
要总结TC免疫疗法最近的临床试验.

主要方法:

关于甲状腺癌生物学和瘤微环境的文献综述.
在TC TME中分析免疫细胞群 (例如TAM,MDSC,Treg) 和分子因子 (例如PD-L1,CTLA-4,IDO1) 的分析.
对TC免疫疗法的临床试验数据的检查.

主要成果:

TC细胞通过招募特定的免疫细胞和表达免疫检查点分子来积极创建免疫抑制的TME.
关键的免疫抑制细胞包括与瘤相关的巨细胞 (TAMs),髓质衍生抑制细胞 (MDSCs) 和调节性T细胞 (Tregs).
像PD-L1和CTLA-4这样的免疫检查点,以及像IDO1这样的酶,由TC细胞表达,有助于免疫逃避.

结论:

在甲状腺癌的发病和免疫逃避中,TME起着至关重要的作用.
针对TiME,特别是通过免疫疗法,为TC提供了一个有希望的治疗策略,特别是在耐火病例中.
进一步的研究和临床试验对于优化甲状腺癌免疫治疗方法至关重要.

关键词:

在PD-L1中.免疫疗法免疫疗法代谢重编程是指代谢重编程.甲状腺癌是一种癌症.瘤免疫微环境是一个微环境.

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