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650nm红光疗法通过阿迪波内克介导的免疫代谢重编程减轻了败血症引起的急性肺损伤
Yiqiu Zhang1, Wei Ni2, Jianghan Li1
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in immunology
|February 9, 2026
概括
红光光生物调制 (PBM) 通过重编程免疫细胞并保持线粒体功能,改善了败血症引起的急性肺损伤 (ALI) 的存活率. 这种非侵入性疗法利用阿迪波涅克信号来减少炎症并促进肺部的修复.
科学领域:
- 免疫学 免疫学 免疫学
- 线粒体生物学 线粒体生物学
- 再生医学是一种再生医学.
背景情况:
- 败血症引起的急性肺损伤 (ALI) 涉及免疫失调和线粒体功能障碍.
- 单细胞/巨细胞反应是ALI的关键,但缺乏有效的免疫代谢治疗方法.
- 这项研究研究了650nm红光光生物调节 (PBM) 作为感染性ALI的潜在治疗方法.
研究的目的:
- 为了确定650nm红光PBM是否可以缓解败血症ALI.
- 为了研究PBM对髓状细胞反应和线粒体功能的影响.
- 探索阿迪波涅克丁信号传递在PBM治疗机制中的作用.
主要方法:
- 在小鼠中,通过结和穿孔 (CLP) 诱导了败血性ALI.
- 小鼠接受了650nm的PBM;评估了生存率,肺损伤标志物和免疫细胞概况.
- 在体外研究中使用LPS刺激的巨细胞来评估PBM对细胞生物能学和炎症标记物的影响,有或没有Adiporo1敲击.
主要成果:
- 在性ALI小鼠中,PBM显著改善了生存率,减少了肺,并增强了肺组织学.
- PBM调节免疫细胞种群,减少炎症性巨细胞和增加修复性巨细胞.
- PBM提高了阿迪波涅克丁水平和维护了线粒体功能 (ATP,减少ROS,改善了膜潜力),这些影响取决于AdipoR1信号传递.
结论:
- 650nm红光PBM通过调节髓状细胞的招募和极化,有效地治疗败血性ALI.
- 通过阿迪波尼克丁-阿迪波R1信号传递,PBM保留了线粒体功能,提供了一种新的免疫代谢干预.
- 红灯PBM提出了一个机械支持的,非侵入性治疗策略,用于败血症相关的肺损伤.
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