免疫类型表达TCF1表达TILs:在可手术的非小细胞肺癌中进行空间分析和预后价值
Konstantinos Ntostoglou1, Georgios Christodoulopoulos2,3, Katie Stoker4,5,6
1Hellenic Oncology Research Group (HORG), Athens, Greece.
Frontiers in immunology
|February 9, 2026
概括
表达T细胞因子1 (TCF1) 的瘤透淋巴细胞 (TIL) 在非小细胞肺癌 (NSCLC) 中具有不同的预后影响. 瘤中心的TCF1+CD8+T细胞是负的预后标记,而侵袭前端的TCF1+CD4+T细胞是正的标记.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 瘤透淋巴细胞 (TIL) 的空间分布和功能异质性会影响非小细胞肺癌 (NSCLC) 患者的治疗结果.
- 表达T细胞因子1 (TCF1) 的TILs对于抗瘤免疫是至关重要的,但它们的子集,定位和瘤微环境中的临床意义尚未明确.
研究的目的:
- 在NSCLC瘤微环境中的TCF1+免疫细胞子集的特征.
- 调查TCF1+TILs与患者结局相关的局部化和预后意义.
主要方法:
- 在102个NSCLC瘤上进行多重免疫组织化学和免疫光,分析瘤中心 (TC) 和侵入性前部 (IF).
- 与单细胞RNA测序数据集和临床结果分析的整合.
- 生存分析,包括无病生存的多变量分析 (DFS).
主要成果:
- 在TCF1+细胞中,CD4+T细胞和CD79α+B细胞占主导地位;CD8+T细胞是少数,特别是在TC细胞中.
- PD1+TCF1-细胞 (终端分化耗尽的TIL) 在TC和IF中比PD1+TCF1+细胞更频繁.
- 在TC中增加的CD8+TCF1+细胞和癌细胞TCF1表达是DFS的负预后标志物.
- 在IF中增加的CD4+TCF1+细胞是DFS的积极预后标志物.
- PD-L1阳性与增加的CD8+和PD1+TCF1-细胞透和有利的DFS相关,特别是在TC.
结论:
- 支持一个精细的框架来评估跨细胞群的TCF1+TIL和TCF1表达.
- TCF1+ TILs及其定位对可操作的NSCLC的预后有重大影响.
- 了解TCF1+TIL异质性可以为NSCLC的未来治疗策略提供信息.
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