评估美国高密度脂蛋白相关炎症指数与胆结石疾病之间的联系 大人的成年人
Chang Fu1, Junhong Chen1, Kai Liu1
1Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, China, jlu.edu.cn.
高水平的HDL相关的炎症指数,如LHR和MHR,与增加胆结石疾病的风险有关. 这些简单的血液标记物为早期胆结石风险评估提供了具有成本效益的方法.
科学领域:
- 消化系统健康 消化系统健康
- 代谢和炎症性疾病
- 生物标志物发现发现
背景情况:
- 胆结石疾病与炎症和脂质代谢有关.
- 高密度脂蛋白 (HDL) 相关的炎症标志物是免疫反应的关键指标.
- 了解HDL指数与胆结石形成之间的联系至关重要.
研究的目的:
- 为了研究HDL相关的炎症指数和胆结石疾病之间的关联.
- 为了评估胆结石风险的淋巴细胞与HDL胆固醇 (LHR) 等比率的预测值.
主要方法:
- 利用了2017-2020年和2021-2023年国家健康和营养检查调查 (NHANES) 的数据.
- 采用加权多变量逻辑回归和限制立方线 (RCS) 分析.
- 进行子组分析,以确保结果在不同人群中一致.
主要成果:
- 在LHR,单细胞与HDL胆固醇比率 (MHR),中性粒细胞与HDL胆固醇比率 (NHR) 和血小板与HDL胆固醇比率 (PHR) 和胆结石疾病的较高四分位数之间发现了显著的正相关性.
- 与最低四分位数相比,观察到增加LHR (58.6%),MHR (67.6%),NHR (68.7%) 和PHR (42.7%) 的胆结石疾病风险增加.
- 这种关联在女性,非糖尿病患者,非高血压患者,非吸烟者和酒精消费者中更为强烈.
结论:
- 与HDL相关的炎症指数在全国样本中显示出与胆结石疾病的正相关性.
- 这些指数可以从常规血液检测中计算出来,为风险分层提供了一个具有成本效益的工具.
- 潜在的早期检测和大规模查的个人有胆结石疾病的风险.
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