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在一次性暴露于静脉注射索尔德罗尼酸后的Fanconi综合征
Rita Deb1, Muhammad Elboghdady1, Alvin Shrestha2
1St George's University Hospitals NHS Foundation Trust London UK.
Clinical case reports
|February 9, 2026
概括
用于治疗骨质疏松症的单一剂量佐莱德龙酸,在一个具有正常功能的老年妇女中引起了Fanconi综合征. 这种罕见的毒性强调了即使没有先前的病,也需要保持警.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 双酸盐,包括Zoledronic酸,是骨质疏松症和骨相关并发症的标准治疗方法.
- 毒性是一种已知的,虽然不常见的,酸治疗的并发症.
- 芬科尼综合征是一种罕见的管状脏疾病.
研究的目的:
- 报告Fanconi综合征的病例,该病例发生在正常功能患者的单次静脉注射佐勒龙酸剂后.
- 审查有关酸诱导的毒性和Fanconi综合征的文献.
- 强调佐勒龙酸有可能导致严重的脏不良事件,即使在没有先前存在脏疾病的患者中也是如此.
主要方法:
- 一个老年女性患者的病例报告.
- 关于酸相关的毒性和Fanconi综合征的文献综述.
- 分析患者的功能之前和之后的zoledronic酸的管理.
主要成果:
- 患者在一次静脉注射索尔德罗尼酸剂后发展出Fanconi综合征,尽管基线功能正常.
- 文献搜索揭示了与勒龙酸相关的Fanconi综合征的现有病例,主要是患有恶性瘤的患者.
- 这种病例代表了Fanconi综合征的第一个实例之一,在正常功能患者中,单次暴露于Zoledronic酸后.
结论:
- 佐勒多尼酸可以诱导显著的毒性,包括Fanconi综合征,即使在正常功能患者单次服用后.
- 对于临床医生来说,意识到这种潜在的不良影响至关重要,特别是在为骨质疏松症开处方索莱德龙酸时.
- 需要进一步研究龙酸诱导的Fanconi综合征的机制和危险因素.
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