塔利多米德作为治疗狗多发性骨髓瘤的救援方案:多中心回顾性研究的初步数据
Stefano Ciccarelli1, Chiara Leo2, Chiara Perrone1
1Department of Veterinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Frontiers in veterinary science
|February 9, 2026
概括
当标准疗法失败时,thalidomide显示出作为安全有效的救援治疗犬多发性骨髓瘤 (MM) 的承诺. 这种免疫调节药物改善了对常规化疗耐药的狗的结果,这表明了对狗MM的新治疗途径.
科学领域:
- 兽医瘤学 兽医瘤学
- 免疫调节药物 免疫调节药物
- 狗癌症研究 狗癌症研究
背景情况:
- 狗多发性髓瘤 (MM) 的治疗依赖于化剂和皮质类固醇.
- 治疗失败和毒性限制了标准MM协议在狗中的有效性.
- 塔利多米德是一种已知的人类MM药物,在兽医中还没有得到充分的研究.
研究的目的:
- 评估thalidomide作为犬类MM的救援疗法的临床疗效和安全性.
- 评估thalidomide在MM不耐药或不能耐受标准治疗的狗中的有效性.
主要方法:
- 从三个转诊中心的医疗记录进行了回顾性研究.
- 包括MM的狗在之前的化疗 (梅尔法兰+/-环胺) 失败或不耐受之后接受了thalidomide.
- 分析了治疗持续时间,反应率,不良事件,无进展生存期 (PFS) 和整体生存期 (OS).
主要成果:
- 在7只狗中,有5只 (71%) 获得或维持了对thalidomide的完全反应.
- thalidomide治疗导致PFS的中位数为490天,显著超过melphalan的180天.
- 副作用是轻微的 (两只狗的II级昏迷);没有报告显著的血液学,肠道或尿道毒性.
结论:
- 沙利多米德表现出良好的耐受性和潜在的有效性,作为犬类MM的救援疗法.
- 它为那些对常规化疗不反应或不耐受的狗提供了可行的选择.
- 建议进行进一步的前性研究,以探索 thalidomide 在第一线或组合协议中用于狗MM.
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