前美国能源部工作人员的慢性阻塞性肺病:并发病和肺功能变化
Sara Howard1,2, Louis Rocconi3, Agricola Odoi2
1Epidemiology and Exposure Science, Oak Ridge Associated Universities, Oak Ridge, TN, United States of America.
PeerJ
|February 9, 2026
概括
接烟雾和二氧化等职业暴露对长期阻塞性肺病 (COPD) 的前能源部 (DOE) 工作人员的肺功能下降有显著影响. 这些预测因素与一般人群中的不同.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 显著影响发病率和死亡率,通常由影响结果的并发症复杂化.
- 有限的数据存在于职业队列中的COPD并发症,可能与一般人群不同.
- 了解这些差异对于评估COPD结果,如肺功能变化至关重要.
研究的目的:
- 识别和描述能源部 (DOE) 前雇员中的COPD并发症集群.
- 将这些群体与一般人群中发现的群体进行比较.
- 确定这个职业队列中肺功能变化和衰退的预测因素.
主要方法:
- 利用来自国家补充查计划的临床,职业和社会人口统计数据.
- 采用等级聚类来识别并发症集群.
- 使用随机森林模型来确定一秒钟内强制呼气体积 (FEV1) 变化和下降的预测因素.
主要成果:
- 在17,448名患有COPD的DOE工人中发现了四个并发症集群.
- 集群包括低并发症,高心血管疾病,高肺癌和高多重并发症患病率.
- 雇佣年龄,接烟雾暴露和二氧化暴露是FEV1变化和下降的显著预测因素,与此队列中的吸烟不同.
结论:
- 在美国能源部的前员工中发现了明显的COPD并发症集群.
- 肺功能变化和衰退的预测因素,如职业暴露,与普通人群不同.
- 结果可以为职业COPD的有针对性的监测和控制计划提供信息.
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